Name: Cheesy Chicken Alfredo Lasagna
Prep time: 1 h
Cook time: 1 h 10 min
Total time: 2 h 30 min
Yield: 10 servings
Ingredients: 1 lb boneless, skinless chicken breasts or tenderloins; 1 tbsp olive oil; 1 tsp garlic powder; 1/2 tsp onion powder; 1/2 tsp dried Italian seasoning; Salt, to taste; Freshly ground black pepper, to taste; 12-15 lasagna noodles (oven-ready or traditional); 1/2 cup (1 stick) unsalted butter; 4 cloves garlic, minced; 1/2 cup all-purpose flour; 4 cups whole milk, warmed; 1 cup heavy cream; 1/4 tsp ground nutmeg (optional); 1.75 cups Parmesan cheese, grated (divided); 1 cup Pecorino Romano cheese, grated; 8 oz cream cheese, softened, cubed; 15 oz ricotta cheese; 1 large egg; 1/4 cup fresh parsley, chopped (divided); 2 cups mozzarella cheese, shredded; 1 cup provolone cheese, shredded

Cheesy Chicken Alfredo Lasagna is not just another weeknight meal; it’s a culinary masterpiece that promises to transform your dinner table into an Italian-American dream. Imagine tender pieces of seasoned chicken, generously coated in a luscious, homemade Alfredo sauce, all nestled between layers of perfectly cooked lasagna noodles and an abundance of melted, golden cheese. This isn’t your nonna’s traditional lasagna, but a brilliant fusion that takes the beloved comfort of classic lasagna and infuses it with the rich, creamy decadence of chicken Alfredo. While lasagna itself holds a venerable place in Italian culinary history, evolving over centuries, this particular rendition embraces a modern, comforting twist, bringing together two cherished flavors in one irresistible casserole.

Why This Dish Will Be Your New Favorite

People adore this dish for its unparalleled creaminess, its satisfying heartiness, and the sheer joy of every cheesy, flavorful bite. It’s the ultimate comfort food, perfect for family dinners, special occasions, or simply when you crave something truly indulgent. I am absolutely thrilled to guide you through creating this magnificent Cheesy Chicken Alfredo Lasagna, a dish that consistently receives rave reviews and requests for seconds. Its irresistible combination of textures and flavors makes it a standout.

Ingredients:

1 pound (about 2-3) boneless, skinless chicken breasts, or chicken tenderloins
1 tablespoon olive oil
1 teaspoon garlic powder
1/2 teaspoon onion powder
1/2 teaspoon dried Italian seasoning
Salt and freshly ground black pepper, to taste
12-15 lasagna noodles (oven-ready or traditional, if using traditional, see notes in instructions)
1/2 cup grated Parmesan cheese, for topping
Fresh parsley, chopped, for garnish (optional)

For the Homemade Alfredo Sauce:

1/2 cup (1 stick) unsalted butter
4 cloves garlic, minced
1/2 cup all-purpose flour
4 cups whole milk, warmed slightly
1 cup heavy cream
1 teaspoon salt, or to taste
1/2 teaspoon freshly ground black pepper, or to taste
1/4 teaspoon ground nutmeg (optional, but adds a lovely warmth!)
1 cup freshly grated Parmesan cheese, plus 1/2 cup for the sauce (total 1.5 cups)
1 cup freshly grated Pecorino Romano cheese
8 ounces cream cheese, softened and cut into cubes

For the Cheesy Layers:

15 ounces ricotta cheese
1 large egg
1/4 cup freshly grated Parmesan cheese
1/4 cup chopped fresh parsley
1/2 teaspoon salt
1/4 teaspoon freshly ground black pepper
2 cups shredded mozzarella cheese
1 cup shredded provolone cheese

Preparing the Chicken Filling:

Let’s kick things off by preparing our star protein for this glorious Cheesy Chicken Alfredo Lasagna – the chicken! This step is all about getting those tender, flavorful pieces ready to mingle with our rich Alfredo sauce and creamy cheeses.

First, take your boneless, skinless chicken breasts and place them on a clean cutting board. Using a sharp knife, carefully cut them into bite-sized pieces, aiming for roughly 1/2-inch to 3/4-inch cubes. This size is perfect because it allows the chicken to cook evenly and ensures you get a piece of tender chicken in every single bite of our delightful Cheesy Chicken Alfredo Lasagna.
Once your chicken is diced, transfer it to a medium bowl. Now, let’s infuse it with some wonderful flavor. Sprinkle the chicken with garlic powder, onion powder, dried Italian seasoning, a good pinch of salt, and a generous crack of fresh black pepper. Toss everything together really well, making sure each piece of chicken is nicely coated with our seasoning blend. This pre-seasoning step is crucial for building layers of flavor in our finished dish.
Next, grab a large skillet or a non-stick pan and place it over medium-high heat. Add the olive oil and let it shimmer for a moment. Once the oil is hot and ready, carefully add the seasoned chicken pieces to the skillet in a single layer. Try not to overcrowd the pan; if your skillet isn’t large enough, you might want to cook the chicken in two batches. This allows the chicken to brown beautifully instead of steaming.
Cook the chicken for about 5-7 minutes, stirring occasionally, until it’s golden brown on the outside and fully cooked through. You’ll know it’s done when there’s no pink visible in the center. The browning adds a fantastic depth of flavor and texture that will complement the creaminess of the Alfredo sauce perfectly.
Once cooked, remove the chicken from the skillet and set it aside. We want to make sure it’s ready to be incorporated into our spectacular Cheesy Chicken Alfredo Lasagna layers when the time comes. Don’t worry about cleaning the pan just yet; we’ll move on to our next delicious component.

Crafting the Homemade Alfredo Sauce:

Now, for the heart and soul of our Cheesy Chicken Alfredo Lasagna – a luxuriously creamy, unbelievably rich homemade Alfredo sauce. Trust me, making it from scratch is absolutely worth the effort, and it’s surprisingly straightforward!

In the same large skillet you used for the chicken (or a clean, large, deep pot if you prefer), melt the entire stick of unsalted butter over medium heat. We want it to be perfectly golden and fragrant.
Once the butter has melted, add the minced garlic. Sauté the garlic for about 1 minute, stirring constantly, until it becomes wonderfully aromatic. Be careful not to let it brown or burn, as burnt garlic can taste bitter. We’re just looking to release its delightful scent.
Now, sprinkle the all-purpose flour over the melted butter and garlic. This is where we create our roux, which is the base that will thicken our sauce. Whisk continuously for 1-2 minutes, allowing the flour to cook out. You’ll notice it form a thick paste. This step is essential to prevent a raw flour taste in your sauce. The mixture should look slightly golden, like a pale blonde roux.
Gradually, and I mean gradually, whisk in the slightly warmed whole milk, a cup at a time. The reason we warm the milk a bit is to prevent lumps and help it incorporate smoothly into the roux. Keep whisking vigorously as you add each cup to ensure a perfectly smooth consistency. If you add it too quickly, you might end up with lumps, which we definitely want to avoid for our luscious Alfredo sauce.
Once all the milk has been incorporated and the mixture starts to thicken, pour in the heavy cream. Stir it in thoroughly. At this point, the sauce will begin to transform into that beautiful, velvety texture we’re aiming for. Bring the mixture to a gentle simmer, still whisking occasionally, and let it cook for about 5-7 minutes, or until it coats the back of a spoon. It will thicken considerably.
Remove the skillet from the heat. This is crucial before adding the cheese to prevent it from seizing or becoming stringy. Now, let’s get cheesy! Add the 1 cup of freshly grated Parmesan cheese, the entire cup of freshly grated Pecorino Romano cheese, and the softened cream cheese cubes.
Stir continuously with your whisk or a sturdy spatula until all the cheeses are completely melted and the sauce is wonderfully smooth and creamy. The cream cheese adds an incredible richness and helps achieve that ultra-silky texture that defines a truly great Alfredo sauce.
Finally, season your glorious Alfredo sauce with salt, freshly ground black pepper, and if you’re feeling adventurous (and I highly recommend it!), the ground nutmeg. Stir well and taste. Adjust the seasonings as needed. You want this sauce to be vibrant and flavorful, as it’s a cornerstone of our Cheesy Chicken Alfredo Lasagna. Set this exquisite sauce aside, keeping it warm if possible, or give it a quick whisk before using if it cools down.

Preparing the Lasagna Noodles and Ricotta Mixture:

While our chicken is cooked and our Alfredo sauce is simmering with cheesy goodness, let’s get the other foundational elements of our Cheesy Chicken Alfredo Lasagna ready. These steps are quick but important for a perfect texture and incredible flavor in every layer.

For Traditional Lasagna Noodles: If you’re using traditional, uncooked lasagna noodles (not oven-ready), bring a large pot of heavily salted water to a rolling boil. Add the lasagna noodles, ensuring they don’t stick together. Cook them according to package directions until they are al dente – meaning they should be firm to the bite, but not hard. Overcooking them will make them mushy in the finished lasagna. Once cooked, drain the noodles thoroughly and rinse them under cold water to prevent them from sticking together. Lay them out flat on parchment paper or a clean kitchen towel to prevent them from clumping. This step helps create distinct, perfectly cooked layers.
For Oven-Ready Lasagna Noodles: If you’re opting for oven-ready noodles, you can skip the boiling step! These noodles are designed to soften and cook right in the oven with all the moisture from our amazing sauce. This can be a real time-saver, and they work beautifully in this Cheesy Chicken Alfredo Lasagna recipe.
Prepare the Ricotta Mixture: In a medium-sized mixing bowl, combine the entire 15 ounces of ricotta cheese, the large egg, 1/4 cup of freshly grated Parmesan cheese, the 1/4 cup of chopped fresh parsley, 1/2 teaspoon of salt, and 1/4 teaspoon of freshly ground black pepper. Use a spoon or spatula to mix all these ingredients together until they are well combined and smooth. The egg acts as a binder, helping the ricotta layer hold its shape and adding a lovely richness. The parsley adds a fresh, herbaceous note that brightens up the entire dish. Set this incredibly flavorful ricotta mixture aside; it’s going to add such a wonderful contrast to our creamy Alfredo!
Shred Your Cheeses: If you haven’t already, take a moment to shred your mozzarella and provolone cheeses. Using freshly shredded cheese, rather than pre-shredded, makes a noticeable difference in how smoothly and evenly the cheese melts. It ensures a truly gooey, stringy, and irresistible cheese pull in every slice of your finished Cheesy Chicken Alfredo Lasagna. Combine the 2 cups of shredded mozzarella and 1 cup of shredded provolone in a bowl and gently toss them together. This blend gives us fantastic melt and flavor.

Assembling Your Cheesy Chicken Alfredo Lasagna:

This is where the magic truly comes together! Layering our beautiful ingredients meticulously is key to achieving a show-stopping Cheesy Chicken Alfredo Lasagna with distinct, delicious strata. Get ready to build something amazing!

Prepare Your Baking Dish: First things first, grab a 9×13-inch baking dish. We want to ensure our lasagna doesn’t stick, so lightly grease the bottom and sides of the dish with a little butter or cooking spray. This also helps with easy serving later.
The First Sauce Layer: Pour about 1 cup of your glorious homemade Alfredo sauce evenly over the bottom of the prepared baking dish. Spread it out with the back of a spoon to create a thin, consistent layer. This base layer not only prevents the noodles from sticking but also infuses the very bottom of our Cheesy Chicken Alfredo Lasagna with that incredible flavor.
The First Noodle Layer: Arrange 3-4 lasagna noodles (depending on their size and how snugly they fit) over the Alfredo sauce. Overlap them slightly if necessary. If you’re using oven-ready noodles, make sure they are completely covered by sauce in each layer; this is how they cook. If using traditional noodles, just lay them flat. You might need to break a noodle or two to fit into the corners or fill gaps, which is perfectly fine.
The Ricotta Layer: Dollop about half of your prepared ricotta cheese mixture evenly over the noodles. Use a spoon or an offset spatula to gently spread it out to the edges. Don’t press too hard; just create an even layer. The creamy, herby ricotta adds a wonderful tang and lightness that balances the richness of the Alfredo.
The Chicken Layer: Scatter about half of your cooked, seasoned chicken pieces evenly over the ricotta layer. Ensure good distribution so every slice of Cheesy Chicken Alfredo Lasagna gets a generous portion of that tender chicken.
The Cheese Blend Layer: Sprinkle about 1/3 of your shredded mozzarella and provolone cheese blend over the chicken and ricotta. This starts building that fantastic cheesy pull we all crave!
More Alfredo Sauce: Drizzle another 1 to 1.5 cups of Alfredo sauce over the cheese. We want to keep everything moist and flavorful, so don’t be shy with the sauce!
Repeat the Layers: Now, let’s repeat the entire sequence. Lay another 3-4 lasagna noodles over the sauce. Follow with the remaining half of the ricotta mixture, spreading it evenly. Then, layer the remaining cooked chicken pieces over the ricotta.
Another Cheese Blend Layer: Sprinkle another 1/3 of your shredded mozzarella and provolone cheese blend over the chicken.
Final Noodle Layer: Place your final layer of 3-4 lasagna noodles over the cheese. Again, adjust as needed to cover the surface. This will be the top structural layer.
The Grand Finale – Top Layers: Pour the remaining Alfredo sauce generously over this last layer of noodles, making sure to cover them completely. We want every inch of those noodles to cook beautifully and absorb all that wonderful flavor.
The Ultimate Cheese Topping: Finally, sprinkle the remaining 1/3 of your shredded mozzarella and provolone blend over the top of the Alfredo sauce. This will create a beautiful golden, bubbly crust when baked. For an extra touch of savory sharpness, scatter the 1/2 cup of grated Parmesan cheese over this top layer. This Parmesan will crisp up wonderfully and add another dimension of flavor to our magnificent Cheesy Chicken Alfredo Lasagna.

Baking the Cheesy Chicken Alfredo Lasagna:

We’re on the home stretch! The baking process is where all those incredible layers of flavor and texture meld together into one harmonious, unbelievably delicious Cheesy Chicken Alfredo Lasagna. Patience during this step will be richly rewarded!

Preheat Your Oven: Begin by preheating your oven to 375°F (190°C). It’s important to have the oven at the correct temperature before you put the lasagna in, ensuring even cooking from the start.
Prepare for Baking: Loosely cover the baking dish with aluminum foil. The key word here is “loosely.” You don’t want the foil to touch the cheese too much, or it will stick. You can create a little tent by doming the foil slightly, or spray the underside of the foil with cooking spray to prevent sticking. Covering the lasagna for the initial baking period helps to steam the noodles (especially if using oven-ready ones) and allows all the flavors to meld without the top getting too brown too quickly. This also ensures that the internal temperature rises evenly throughout.
First Bake: Carefully place the covered lasagna in your preheated oven. Bake for 30 minutes. During this time, the noodles will soften, the sauces will bubble, and the cheeses will begin their beautiful melty transformation deep within the layers. You’ll likely start to smell the incredible aromas filling your kitchen, building anticipation for the feast to come!
Uncover and Finish Baking: After 30 minutes, carefully remove the foil from the baking dish. Now we want to achieve that gorgeous golden-brown, bubbly top crust. Return the uncovered Cheesy Chicken Alfredo Lasagna to the oven and continue baking for another 20-25 minutes. Keep an eye on it during this final stage. You’ll know it’s done when the edges are bubbling vigorously, the sauce is visibly hot and steamy, and the top layer of cheese is beautifully golden brown with some crispy, caramelized edges. If you like your top even more browned or blistered, you can briefly switch to the broiler for the last minute or two, but watch it like a hawk to prevent burning!
The Crucial Resting Period: This step is arguably just as important as the baking itself for a perfect slice of lasagna. Once your Cheesy Chicken Alfredo Lasagna comes out of the oven, it will be incredibly hot and still actively bubbling. Resist the urge to dive in immediately! Cover the baking dish again, loosely, with foil and let it rest on a wire rack for at least 15-20 minutes before cutting and serving. This resting time allows the layers to set, the sauces to redistribute, and the cheese to firm up just enough so that your slices hold together beautifully when you serve them. If you cut it too soon, it might collapse into a delicious but messy pile.
Garnish and Serve: Once rested, slice your magnificent Cheesy Chicken Alfredo Lasagna into generous portions. Garnish with a sprinkle of fresh chopped parsley, if desired, to add a pop of color and freshness. Serve immediately and prepare for rave reviews! This rich, comforting dish pairs wonderfully with a simple green salad and some crusty garlic bread to soak up any extra sauce. Enjoy every single indulgent bite of your homemade creation!

Conclusion:

My culinary journey creating this dish has been an absolute delight, and I truly believe that once you experience it, you’ll understand why it has quickly become a new favorite in my kitchen. This isn’t just another pasta dish; it’s a harmonious blend of creamy, cheesy Alfredo sauce, tender, seasoned chicken, and perfectly al dente lasagna noodles, all baked to golden, bubbling perfection. Imagine the rich, savory aroma filling your home as it bakes, promising a meal that is both profoundly comforting and undeniably elegant. Each bite delivers a symphony of textures and flavors: the delicate chew of the pasta, the succulent chicken, the luxurious, velvety Alfredo, and of course, the glorious melty cheese pull that makes every forkful a moment of pure bliss. It’s hearty without being heavy, indulgent yet balanced, and absolutely guaranteed to impress even the most discerning palates. This recipe for Cheesy Chicken Alfredo Lasagna is more than just food; it’s an invitation to create warmth, joy, and unforgettable memories around your dinner table. It’s a dish that speaks of celebration, even if the only occasion is simply making it through a busy Tuesday. I wholeheartedly believe it’s a must-try because it takes familiar, beloved components and elevates them into something truly spectacular, offering a unique twist on classic comfort food that stands out from the crowd. The effort, while not insignificant, is immensely rewarding, and the results are truly spectacular.

Elevate Your Dining Experience: Serving Suggestions & Creative Variations

Now that you’re practically salivating at the thought of this incredible dish, let’s talk about how to make it an even more unforgettable meal. For serving, I always recommend pairing this rich lasagna with something fresh and bright to cut through its delicious creaminess. A simple, crisp green salad dressed with a tangy vinaigrette is perfect. Think mixed greens, a few cherry tomatoes, and maybe some slivered red onion or cucumber. Another fantastic accompaniment is a warm, crusty loaf of garlic bread – ideal for mopping up any stray sauce. If you want to add a bit more vegetable goodness, a side of lightly steamed or roasted asparagus, broccoli, or green beans would also be wonderful. The key is to balance the richness with freshness and texture.

But the beauty of this recipe extends beyond just serving; it’s incredibly versatile and open to your own creative flair! Don’t hesitate to put your unique spin on it. For instance, if you love a bit of heat, a pinch or two of red pepper flakes mixed into the Alfredo sauce or layered between the noodles will add a lovely kick. To boost the vegetable content and add more color, consider sautéing some fresh spinach or sliced mushrooms with the chicken before layering. Sun-dried tomatoes or roasted red peppers, roughly chopped, would also introduce a fantastic depth of flavor and a beautiful visual appeal. If you’re a cheese connoisseur, feel free to experiment with different varieties; a layer of smoked provolone, fontina, or even a little bit of goat cheese in certain layers could introduce exciting new dimensions. While the chicken is central, you could also experiment with other proteins. Cooked shrimp or crumbled Italian sausage would make excellent substitutes or additions, transforming the dish in new and exciting ways. For a vegetarian option, simply omit the chicken and load up on your favorite vegetables like zucchini, eggplant, or even some hearty chickpeas or white beans to ensure it remains satisfying. This recipe is robust enough to handle your culinary imagination, so feel empowered to make it truly your own.

Your Culinary Adventure Awaits!

So, there you have it – my enthusiastic endorsement and a whole host of ideas to make this dish uniquely yours. I truly hope I’ve managed to convey the sheer deliciousness and satisfaction that comes from preparing and enjoying this spectacular creation. This isn’t just a recipe to follow; it’s an invitation to embark on a delightful culinary adventure that will fill your home with warmth and your belly with pure comfort. Trust me when I say, the joy of seeing your friends and family’s faces light up when they take their first bite of this Cheesy Chicken Alfredo Lasagna is an unparalleled reward. I’m genuinely excited for you to experience the magic of this dish firsthand. So, what are you waiting for? Gather your ingredients, put on your favorite apron, and dive into this incredible cooking experience. Once you’ve whipped up your masterpiece, please don’t keep it to yourself! I would absolutely love to hear all about your experience. Did you add any unique twists? What was your favorite part? Share your photos, your triumphs, and even your culinary learnings in the comments below. Your feedback and creativity inspire me and the entire cooking community. Happy cooking, and I can’t wait to hear how much you loved it!